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Thursday, December 18, 2008

A team of eight transplant surgeons in Cleveland Clinic in Ohio, USA, led by reconstructive surgeon Dr. Maria Siemionow, age 58, have successfully performed the first almost total face transplant in the US, and the fourth globally, on a woman so horribly disfigured due to trauma, that cost her an eye. Two weeks ago Dr. Siemionow, in a 23-hour marathon surgery, replaced 80 percent of her face, by transplanting or grafting bone, nerve, blood vessels, muscles and skin harvested from a female donor’s cadaver.

The Clinic surgeons, in Wednesday’s news conference, described the details of the transplant but upon request, the team did not publish her name, age and cause of injury nor the donor’s identity. The patient’s family desired the reason for her transplant to remain confidential. The Los Angeles Times reported that the patient “had no upper jaw, nose, cheeks or lower eyelids and was unable to eat, talk, smile, smell or breathe on her own.” The clinic’s dermatology and plastic surgery chair, Francis Papay, described the nine hours phase of the procedure: “We transferred the skin, all the facial muscles in the upper face and mid-face, the upper lip, all of the nose, most of the sinuses around the nose, the upper jaw including the teeth, the facial nerve.” Thereafter, another team spent three hours sewing the woman’s blood vessels to that of the donor’s face to restore blood circulation, making the graft a success.

The New York Times reported that “three partial face transplants have been performed since 2005, two in France and one in China, all using facial tissue from a dead donor with permission from their families.” “Only the forehead, upper eyelids, lower lip, lower teeth and jaw are hers, the rest of her face comes from a cadaver; she could not eat on her own or breathe without a hole in her windpipe. About 77 square inches of tissue were transplanted from the donor,” it further described the details of the medical marvel. The patient, however, must take lifetime immunosuppressive drugs, also called antirejection drugs, which do not guarantee success. The transplant team said that in case of failure, it would replace the part with a skin graft taken from her own body.

Dr. Bohdan Pomahac, a Brigham and Women’s Hospital surgeon praised the recent medical development. “There are patients who can benefit tremendously from this. It’s great that it happened,” he said.

Leading bioethicist Arthur Caplan of the University of Pennsylvania withheld judgment on the Cleveland transplant amid grave concerns on the post-operation results. “The biggest ethical problem is dealing with failure — if your face rejects. It would be a living hell. If your face is falling off and you can’t eat and you can’t breathe and you’re suffering in a terrible manner that can’t be reversed, you need to put on the table assistance in dying. There are patients who can benefit tremendously from this. It’s great that it happened,” he said.

Dr Alex Clarke, of the Royal Free Hospital had praised the Clinic for its contribution to medicine. “It is a real step forward for people who have severe disfigurement and this operation has been done by a team who have really prepared and worked towards this for a number of years. These transplants have proven that the technical difficulties can be overcome and psychologically the patients are doing well. They have all have reacted positively and have begun to do things they were not able to before. All the things people thought were barriers to this kind of operations have been overcome,” she said.

The first partial face transplant surgery on a living human was performed on Isabelle Dinoire on November 27 2005, when she was 38, by Professor Bernard Devauchelle, assisted by Professor Jean-Michel Dubernard in Amiens, France. Her Labrador dog mauled her in May 2005. A triangle of face tissue including the nose and mouth was taken from a brain-dead female donor and grafted onto the patient. Scientists elsewhere have performed scalp and ear transplants. However, the claim is the first for a mouth and nose transplant. Experts say the mouth and nose are the most difficult parts of the face to transplant.

In 2004, the same Cleveland Clinic, became the first institution to approve this surgery and test it on cadavers. In October 2006, surgeon Peter Butler at London‘s Royal Free Hospital in the UK was given permission by the NHS ethics board to carry out a full face transplant. His team will select four adult patients (children cannot be selected due to concerns over consent), with operations being carried out at six month intervals. In March 2008, the treatment of 30-year-old neurofibromatosis victim Pascal Coler of France ended after having received what his doctors call the worlds first successful full face transplant.

Ethical concerns, psychological impact, problems relating to immunosuppression and consequences of technical failure have prevented teams from performing face transplant operations in the past, even though it has been technically possible to carry out such procedures for years.

Mr Iain Hutchison, of Barts and the London Hospital, warned of several problems with face transplants, such as blood vessels in the donated tissue clotting and immunosuppressants failing or increasing the patient’s risk of cancer. He also pointed out ethical issues with the fact that the procedure requires a “beating heart donor”. The transplant is carried out while the donor is brain dead, but still alive by use of a ventilator.

According to Stephen Wigmore, chair of British Transplantation Society’s ethics committee, it is unknown to what extent facial expressions will function in the long term. He said that it is not certain whether a patient could be left worse off in the case of a face transplant failing.

Mr Michael Earley, a member of the Royal College of Surgeon‘s facial transplantation working party, commented that if successful, the transplant would be “a major breakthrough in facial reconstruction” and “a major step forward for the facially disfigured.”

In Wednesday’s conference, Siemionow said “we know that there are so many patients there in their homes where they are hiding from society because they are afraid to walk to the grocery stores, they are afraid to go the the street.” “Our patient was called names and was humiliated. We very much hope that for this very special group of patients there is a hope that someday they will be able to go comfortably from their houses and enjoy the things we take for granted,” she added.

In response to the medical breakthrough, a British medical group led by Royal Free Hospital’s lead surgeon Dr Peter Butler, said they will finish the world’s first full face transplant within a year. “We hope to make an announcement about a full-face operation in the next 12 months. This latest operation shows how facial transplantation can help a particular group of the most severely facially injured people. These are people who would otherwise live a terrible twilight life, shut away from public gaze,” he said.

Wednesday, June 6, 2007

Following a world premiere during the Director’s Fortnight at the Cannes Film Festival, the latest film by Thai auteur Pen-Ek Ratanaruang made its Thailand premiere on Tuesday night in a screening for the press and celebrities.

Before the screening of the new film, Ploy, the director and his stars took the rostrum for a question-and-answer session, during which Pen-Ek pulled out a digital camera and took photos of the presenter, the press and the actors.

Ploy is a drama film, about a middle-aged Thai-American couple, portrayed by popular Thai soap opera actress Lalita Panyopas and Pornwut Sarasin, a first-time actor whose day job is working as vice president of Thai Namthip, the distributor of Coca Cola in Thailand. The couple have returned to Thailand for the first time in many years to attend the funeral of a relative.

They arrive at Bangkok’s Suvarnabhumi Airport at 5 a.m. after a long-haul flight from the U.S., and check in to a hotel. The wife, Dang, just wants to sleep, but the husband, Wit, wants some cigarettes, so he goes to the hotel bar to buy some. There, he strikes up a conversation with a 19-year-old girl named Ploy (17-year-old first-time actress Apinya Sakuljaroensuk), who’s waiting at the hotel for her mother.

Wit then invites the girl to his and Dang’s room, so she can take a shower and relax. This poor judgment by Wit ignites feelings of jealousy and anger in Dang, and causes the couple to review their marriage of seven years.

Lao-Australian leading man Ananda Everingham is in a supporting role as the hotel bartender. As a counterpoint to Wit’s and Dang’s bickering, the bartender engages in an erotic tryst with a hotel maid (model-actress Porntip Papanai) in a nearby room.

The press screening was held at SF World Cinemas at CentralWorld shopping mall in Bangkok. Given the presence of Coca-Cola’s Pornwut in the cast, it was perhaps not a coincidence that cans of Coke Zero, a new soft drink that is just being introduced in Thailand, were being doled out for free.

According to early reviews at Cannes, Ploy contains a high level of nudity and eroticism, which is uncommon for a Thai film, because Thailand has no film-ratings system and instead adheres to a strict censorship code that excises nakedness and sex scenes.

Ahead of its Thailand premiere, Aphiradee Iamphungphorn, co-producer for Five Star Production, said she knew the film would have to be re-edited for Thailand, but “hopefully not more than we can bear.” To get past the censors, Pen-ek created a special Thailand edit of the film, in which the sex scenes are toned down.

Ploy is the director’s sixth feature film since he made his debut in 1997 with Fun Bar Karaoke, which premiered at the Berlin International Film Festival. Since then, his films are regularly featured on the festival circuit, and are submitted by Thailand’s film industry for consideration by the Academy Awards for Best Foreign Language Film.

Pen-Ek’s latest film is a return to screenwriting, after his previous two films, Last Life in the Universe and Invisible Waves, were scripted or co-scripted by Thai writer Prabda Yoon. It also marks a reunion with leading actress Lalita, who starred in his second feature, 1999’s black comedy, Ruang Talok 69, as well as Porntip, who co-starred in Pen-Ek’s 2001 musical-comedy-drama Monrak Transistor.

Ploy opens in Thailand cinemas on Thursday.

Saturday, April 14, 2007

A complex series of events, including a five month-old computer error, was responsible for the battery failure that led to the loss of NASA’s Mars Global Surveyor last year, an internal review board says. Findings from a preliminary report released on Friday say that while NASA controllers followed procedures while operating the craft, the procedures did not cover the types of errors that occurred.

According to NASA, on November 2, 2006, the Global Surveyor was ordered to perform a routine adjustment of its solar panels. However, the Global Surveyor reoriented to an angle that exposed one of its two batteries to direct sunlight. The battery overheated, which led to the depletion of both batteries. An incorrect setting in antenna orientation prevented Global Surveyor from relaying its status to NASA controllers. Its preprogrammed systems did not take into account the need to maintain a thermally safe orientation.

That was the last communication that NASA controllers had with the spacecraft.

The Global Surveyor was the first US mission to Mars in twenty years, For ten years, the craft returned detailed information to NASA scientists providing new insights, including evidence that appeared to show the presence of water on Mars and identification of deposits of water-related minerals, which led to selection of a Mars rover landing site.

“The loss of the spacecraft was the result of a series of events linked to a computer error made five months before the likely battery failure,” said Dolly Perkins, board chairperson and deputy director-technical of NASA’s Goddard Space Flight Center.

The board concluded that NASA controllers had followed procedures, but that the procedures did not adequately cover the type of errors that occurred. In its final report, the board will offer recommendations applicable to future missions.

“We are making an end-to-end review of all our missions to be sure that we apply the lessons learned from Mars Global Surveyor to all our ongoing missions,” said Fuk Li, Mars Exploration Program manager at NASA’s Jet Propulsion Laboratory.

The Global Surveyor was the longest operating spacecraft at Mars and had lasted four times longer than expected.

Thursday, August 18, 2005

“Total chaos” is how many described the melee that resulted from a sale of used Apple iBook laptop computers at the Richmond International Raceway (RIR) by the Henrico County, Virginia school system.

Officials estimated nearly 5,000 people thronged the sale for the $50, four-year-old computers. Among them were 17 injured, four requiring hospitalization – one for a leg injury, and three for heat-related illness, said Henrico County Police. Reports of trampling in the stampede were not uncommon, and one driver reportedly tried to drive through the throng of prospective buyers.

Alice Jemerson, an elderly customer said, “They bum rushed the gates and I was knocked over, fighting for my life. All these people were on top of me.”

Shortly after 7am EST officials opened the gates and many residents ran hysterically toward the building where the sale was to occur at 9am.

At a post sale press conference, Henrico County Police spokesman Lieutenant Doug Perry told reporters, “A few bad apples found their way inside. It looked worse than it was.”

Apple iBooks are the preferred computer for Henrico County schools, and Director of General Services of Henrico County Paul Proto, said changes were made to the event after tremendous interest was generated, some as far away as Europe and California. Officials closed and moved the sale from the Henrico county school warehouse to the RIR, after residents complained that their tax dollars were used to buy the computers, and they ought to have first right to repurchase them. The Henrico County Board of Supervisors voted to amend the County Code so that only residents could purchase the laptop computers.

Although officials had prohibited camping out and overnight parking, some in attendance reported that people began arriving at midnight.

Henrico Police Chief H.W. Stanley, Jr. said five patrol officers were originally planned for the event, a customary presence for an event the size authorities had estimated. But by 6 am, an enormous crowd was assembled at the front gate.

Officials present before opening told the crowd that automobiles would be allowed to enter first, which prompted many to run to their cars. But while some were running back to their cars, others rushed the gate. The resulting confusion created much anger, and guards closed the gates shortly thereafter.

Long lines encircling the sale building were commonplace, and one observer noted, “They’re going to see themselves on the news tonight, and see what fools they are.”

Some citizens, however, considered their wait worthwhile. Hairstylist and mother of two Sheress Blunt was one of the first hundred to buy one of the iBooks; she came with her mother and said they sneaked into the raceway through a side gate.

Tonya Vaughan arrived at 5:30 a.m., also bought one of the first iBooks and said three people offered to buy it from her for as much as $200. She declined however, saying, “I told them no way! I had worked too hard for it.”

Lt. Perry said many officers were complimented on the way they handled the crowd, adding that police were seen letting children who had been pushed aside, into the building.

Mr. Proto said, “There are no plans right now to have another iBook sale.”

Henrico County Battalion Police Chief Steve Wood said no arrests were made and the iBooks were sold out by 1pm EST.

Saturday, May 24, 2008

Thailand’s National Film Archive in Salaya, Nakhon Pathom unveiled a new museum and cinema on Thursday night for the 100th anniversary celebration of the birth of Rattana Pestjoni, a filmmaker who is considered the “father of contemporary Thai cinema”.

With Pestonji’s family, movie stars, filmmakers, government officials and fans on hand, the National Film Archive’s museum was opened for tours, and the facility’s 120-seat cinema hosted the screening of a documentary film, Signature: The Life and Work of R.D. Pestonji.

Pestonji was born in Bangkok on May 22, 1908, to a Parsi-Indian (ethnic Persian) family. For his first short film, Tang, in 1937, he received an award from Alfred Hitchcock at a film festival in Scotland. Pestonji directed his first feature film, Dear Dolly, in 1951. He was known for his skills as a cinematographer, and he shot the first Thai feature film to be submitted to an overseas film festival. Pestonji also pushed for innovations in the Thai film industry, such as using 35mm film, and raising the level of cinematography as an artistic element of the films, said film historian Dome Sukwong, director of the National Film Archive.

The now-lost Santi-Weena was submitted to the Asia-Pacific Film Festival in 1954 in Tokyo. Pestonji served as cinematographer on it as well as Forever Yours, in 1955. He then directed four features, Country Hotel in 1957, Dark Heaven in 1958, Black Silk in 1961, and Sugar Is Not Sweet in 1964. His films were never box-office successes, which led to Pestonji retiring from feature-film work to make television commercials, Sukwong said.

Pestonji died of a heart attack on August 17, 1970 at the Montien Hotel Bangkok, while giving a speech to government officials and film industry executives about the prevalence of Hollywood films in Thailand’s cinemas.

Contemporary directors who were influenced by Pestonji include Wisit Sasanatieng and Pen-ek Ratanaruang (Last Life in the Universe). Sasanatieng was among the filmmakers present at Thursday’s event.

“Prae Dum [Black Silk] is the film that remains my single major influence,” Sasanatieng was quoted as saying by the Bangkok Post. Sasanatieng’s colorful features, Tears of the Black Tiger and Citizen Dog bear many of the hallmarks of Pestonji’s films. “Khun Ratana was not simply a master storyteller … he knew how to use color, art direction and camera angles to create subtle nuances and charge the movie with strong emotions.”

Pestonji’s sons, Santa and Edel, have continued in the film business. The Bangkok film production house their father started now houses a firm that hires out equipment and film crews to foreign films shooting on location in Thailand. Films that the company has been involved with include Heaven & Earth and The Beach. Pestonji’s daughter, Ratanavadi Ratanabhand, was the lead actress in 1961’s Black Silk.

The Pestonji centennial celebration was the first major event held in the new facilities at the National Film Archive, which moved around 10 years ago to the Fine Arts Department compound in Nakhon Pathom Province, about 50 kilometers from Bangkok, where the archive had been previously located. The museum and cinema complex were built in the last year, and Thursday’s event was the first major function held at the facility, said Chalida Uabumrungjit of the Thai Film Foundation, which has worked closely with the National Film Archive to preserve Pestonji’s legacy. The foundation holds the rights to Pestonji’s films and plans to issue a DVD set of his works later this year.

The centerpiece of the archive’s museum is a wax figure of Pestonji, seated with his prized Mitchell camera in front of a recreation of the set from his 1957 musical comedy Country Hotel.

In a manner similar to Grauman’s Chinese Theatre in Hollywood, handprints, footprints and signatures of celebrities are being collected in the concrete outside the museum’s cinema. That initiative started on Thursday with actor Prompong Nopparit, a spokesman for the Ministry of Culture, being the first to make his marks.

Other stars making impressions included actor Suthep Wongkamheng, who starred in Pestonji’s Dark Heaven. A rain storm dampened the festivities, but didn’t keep 1970s action star Sombat Metanee from making his mark in the slab, albeit under cover of umbrellas. Other figures adding their marks to the wet cement were pioneering animator Payut Ngaokrachang and Santa Pestonji, Ratana’s eldest son.

Tuesday, May 9, 2006For the first time in three decades, direct and at least partially public diplomatic communication will commence between the United States (US) and Iran. Iranian government spokesman Gholam-Hossein Elham said that Iranian president Mahmoud Ahmadinejad has sent a letter to the U.S. president George W. Bush proposing “new solutions for getting out of international problems and the current fragile situation of the world”.

Mr Gholam-Hossein Elham did not say whether the letter mentioned the nuclear dispute, one of the diplomatic problems currently straining relations between Iran and the USA. This information arrived one day after the Iranian parliament announced that it might retract from the Nuclear Non-Proliferation Treaty (NPT) if Western pressure over its programme was to increase.

Differing reports have been made as to whether or not the letter will be made public, and if so, when. In its online report of 8 May 2006, 09:25 GMT, the BBC quoted Iranian Foreign Ministry spokesman Hamid Reza Asefi as saying that the contents of the letter would be made public once Bush had received it. The updated version of the report of 8 May 2006, 14:52 GMT, quotes Asefi as saying that the contents would be made public “at the right time”. An ABC report quoted Gholam-Hossein Elham as saying “it is not an open letter.”

Iran’s foreign affairs minister, Manouchehr Mottaki, delivered the letter to the United States’ interests section in the Swiss embassy in Tehran on Monday. The United States has not held diplomatic relations with Iran since the 1979 Iranian hostage crisis.

U.S. Secretary of State Condoleezza Rice said “this letter isn’t it. This letter is not the place that one would find an opening to engage on the nuclear issue or anything of the sort.”

“It isn’t addressing the issues that we’re dealing with in a concrete way,” she added.

John R. Bolton, U.S. Ambassador to the United Nations, also read the letter, saying, “I think it is typical of Iran that when major decisions are about to be taken … that they have tried to throw sand in the eyes of the proponents of the action. That’s what this may be.”

The letter has since been put on an official Iranian website, and on Tuesday, Ahmadinejad said “the letter to US President George Bush carries the Iranian nation’s views and comments on international issues as well as suggestions for resolving the many problems facing humanity.”

Friday, January 20, 2006

A recently created Danish clothing company is selling on the internet T-shirts in order to support the clandestine radio station of the Colombian guerrilla group Revolutionary Armed Forces of Colombia (FARC) and the graphical workshop of the Popular Front for the Liberation of Palestine (PFLP). In fact the money will be used by these groups to carry on their terrorist activities. FARC activities include kidnappings, masacres, bombs, extortions and the drug trade.

Fighters and Lovers is selling the T-shirts at 170 DKK (US$27.6), from which 35 DKK (US$5.7) are to be destinated to support both armed groups.

Anna Duever, Fighters and Lovers PR chief, said to Spanish news agency EFE that their objective is to “defend freedom and social justice, which is FARC and PFLP are fighting for”. Duever believes the fact the FARC has been included by the EU in its terrorist group list is a “political game”. “We pay our taxes in Denmark, and that money is used for financing the troops our government has sent to Iraq. That’s terrorism. Besides, in Colombia there’s a regime oppressing population and torturing and killing its people”, she said.

Colombian Foreign Affairs Minister, Carolina Barco, said to local media that “financing terrorist groups is unacceptable and goes against all the international norms. Yesterday [Tuesday 19] our ambassador contacted the Danish government, we sent a protest note and have demanded an explanation.”

A year ago, a Danish NGO named Oprør (“Rebelion”) stated it had donated money to the Colombian guerrilla. A new antiterrorism law in Denmark may punish it.